Calcium signalling in developing cardiomyocytes: implications for model systems and disease. (9th February 2015)

• Record Type: Journal Article
• Authors: Louch, William E.; Koivumäki, Jussi T.; Tavi, Pasi
• Is Part Of: Journal of physiology. Volume 593:Number 5(2015:Mar.)
• Page Start: 1047
• Page End: 1063
• Publication Date: 2015-02-09
• Subjects: Physiology -- Periodicals; 612.005
• DOI: 10.1113/jphysiol.2014.274712
• Languages: English
• ISSNs: 0022-3751

Abstract

Abstract : Abstract: Adult cardiomyocytes exhibit complex Ca 2+ homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca 2+ sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca 2+ homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as cultured neonatal cells and stem cells.