Biofunctional soyasaponin Bb in peanut (Arachis hypogaea L.) sprouts enhances bone morphogenetic protein‐2‐dependent osteogenic differentiation via activation of runt‐related transcription factor 2 in C2C12 cells. (18th March 2019)

• Record Type: Journal Article
• Authors: Kim, Shin‐Hye; Yuk, Heung Joo; Ryu, Hyung Won; Oh, Sei‐Ryang; Song, Duk Young; Lee, Kwang‐Sik; Park, Kie‐In; Choi, Sik‐Won; Seo, Woo Duck
• Is Part Of: Phytotherapy research. Volume 33:Number 5(2019)
• Page Start: 1490
• Page End: 1500
• Publication Date: 2019-03-18
• Subjects: BMP‐2 -- bone -- osteoblasts -- peanut sprouts -- Runx2 -- soyasaponin Bb; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.6341
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Improvement of bone formation is necessary for successful treatment of the bone defects associated with osteoporosis. In this study, we sought to elucidate the osteogenic activity of peanut sprouts and their bioactive components. We found that peanut sprout water extract (PSWE) enhanced bone morphogenetic protein‐2‐mediated osteoblast differentiation in a dose‐dependent manner by stimulating expression of runt‐related transcription factor 2 (Runx2) via activation of AKT/MAP kinases. We identified a major component of PSWE, soyasaponin Bb, as the bioactive compound responsible for improvement of anabolic activity. Soyasaponin Bb from PSWE enhanced expression of the osteogenic transcription factor Runx2 and alkaline phosphatase. The soyasaponin Bb content depended on sprouting time of peanut, and the anabolic action of PSWE was dependent on soyasaponin Bb content. Thus, PSWE and soyasaponin Bb have the potential to protect against bone disorders, including osteoporosis.