Transition‐Metal‐Free Direct Trifluoromethylation and Perfluoroalkylation of Imidazopyridines under Mild Conditions. Issue 7 (12th February 2019)

• Record Type: Journal Article
• Authors: Han, Shuaijun; Gao, Xianying; Wu, Qingsong; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 7(2019)
• Page Start: 1559
• Page End: 1563
• Publication Date: 2019-02-12
• Subjects: Transition-metal-free -- Mild conditions -- Trifluoromethylation -- Perfluoroalkylation -- Imidazopyridines; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201801541
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The first transition‐metal‐free method for direct C−H trifluoromethylation of imidazo[1, 2‐a]pyridine derivatives with readily available Ruppert‐Prakash reagent TMSCF3 under mild conditions was described. Moreover, this method could be applied to direct C−H perfluoroalkylation of imidazopyridines, affording a series of novel perfluoroalkylated products in moderate to good yields. Notable advantages of this protocol include easy operation, high‐efficiency and wide substrate scope. Abstract :