Multi-walled carbon nanotubes modified screen-printed electrodes for cisplatin detection. (10th March 2015)

• Record Type: Journal Article
• Authors: Materon, Elsa M.; Wong, Ademar; Klein, Stanlei I.; Liu, Juewen; Sotomayor, Maria D.P.T.
• Is Part Of: Electrochimica acta. Volume 158(2015)
• Page Start: 271
• Page End: 276
• Publication Date: 2015-03-10
• Subjects: Screen printed electrode -- cisplatin -- multi-walled carbon nanotubes (MWCNT-COOH) -- sodium dodecyl sulphate (SDS) -- differential pulse voltammetry; Electrochemistry -- Periodicals; Electrochemistry, Industrial -- Periodicals; 541.37
• DOI: 10.1016/j.electacta.2015.01.184
• Languages: English
• ISSNs: 0013-4686

Abstract

Highlights: Screen printed electrode modified functionalized multi-walled carbon nanotubes. MWCNT-COOH/SDS/SPCEs sensor to detection cisplatin in human serum samples. Cis-dichlorodiammineplatinum (II) has been extensively used to treat cancer. Characterized by cyclic voltammetry and differential pulse voltammetry. Abstract: A screen printed electrode functionalized with multi-walled carbon nanotubes and factory modified with carboxyl groups (MWCNT-COOH/SPCEs) was characterized by cyclic voltammetry and differential pulse voltammetry in a NaCl (0.1 mol L −1, pH 7) solution containing 800 μmol L −1 sodium dodecyl sulfate (SDS). The MWCNT-COOH/SDS/SPCEs sensor was tested for the detection and quantification of cisplatin. For solutions of cisplatin, the electrochemical analysis showed a linear correlation coefficient of 0.9974 to cisplatin at concentrations between 1.45 × 10 −5 and 1.0 × 10 −4 mol L −1, a sensitivity of 4.4 × 10 4 (±1.0 × 10 3 ) μA L mol −1, and detection and quantification limits of 4.6 × 10 −6 and 1.4 × 10 −5 mol L −1, respectively. The reproducibility of the sensor response evaluated by the analysis of three replicates, indicated a RSD of 3.91%. The excellent response of the MWCNT-COOH/SDS/SPCEs cisplatin sensor allowed it to be tested in samples of human blood serum whose levels of added cisplatin were monitored by the HPLC. The average error % (sensor/HPLC) of 3.4 indicates that the combined methodology of MWCNT-COOH modified SPCE and the addition of a surfactant such as dodecyl sulfate is a convenient alternative for the use of HPLC for cisplatin determination in biological samples. The methodology cannot be applied to non-ionizable antitumor drugs carboplatin, oxaliplatin, doxorubicin or gemcitabine.