A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks. (4th July 2019)
- Record Type:
- Journal Article
- Title:
- A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks. (4th July 2019)
- Main Title:
- A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks
- Authors:
- Bartke, Till
Groth, Anja - Abstract:
- ABSTRACT: Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.
- Is Part Of:
- Molecular & cellular oncology. Volume 6:Number 4(2019)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 6:Number 4(2019)
- Issue Display:
- Volume 6, Issue 4 (2019)
- Year:
- 2019
- Volume:
- 6
- Issue:
- 4
- Issue Sort Value:
- 2019-0006-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-07-04
- Subjects:
- BRCA1 -- BARD1 -- 53BP1 -- DNA double strand break repair -- homologous recombination
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2019.1605820 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 14559.xml