CFTR is not a gluten lover either. (20th December 2018)

• Record Type: Journal Article
• Authors: Vachel, Laura; Muallem, Shmuel
• Is Part Of: EMBO journal. Volume 38:Number 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-20
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2018101200
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Coeliac disease (CD) is an inflammatory autoimmune disease caused by ingestion of gluten proteins, mainly gliadin. Undigested gliadin proline‐rich peptides trigger the innate and adaptive immune response, resulting in intestinal cell stress and damage. A new study by Villella et al (2019 ) addressing the unclear primary cause of intestinal cell stress reports that gliadin peptides inhibit the function of the chloride and bicarbonate channel CFTR, causing intestinal cell stress, which is sufficient to trigger CD symptoms. Notably, CFTR potentiators used to treat cystic fibrosis effectively rescue CFTR function and markedly ameliorate the pathology of coeliac disease. Abstract : New findings reveal the cystic fibrosis‐linked anion channel CFTR as unexpected target of dietary wheat peptides causing intestinal cell stress and coeliac disease.