Type 2 responses at the interface between immunity and fat metabolism. (October 2015)

• Record Type: Journal Article
• Authors: Odegaard, Justin I; Chawla, Ajay
• Is Part Of: Current opinion in immunology. Volume 36(2015)
• Page Start: 67
• Page End: 72
• Publication Date: 2015-10
• Subjects: Immunology -- Periodicals; Allergy -- Periodicals; Immunology -- Abstracts -- Periodicals; Allergy -- Abstracts -- Periodicals; 616.079
• DOI: 10.1016/j.coi.2015.07.003
• Languages: English
• ISSNs: 0952-7915

Abstract

Highlights: Type 2 immunity plays a crucial role in white, brown, and beige adipose tissue. Type 2 immunity acts through ILC2s, eosinophils, Tregs, and macrophages. Type 2 immunity supports white adipose tissue's nutrient storage function. Type 2 immunity provisions nutrients for brown adipose tissue thermogenesis. Type 2 immunity drives precursor proliferation and beiging in white adipose tissue. Abstract : Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect 'healthy' physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.