Host–pathogen interaction during bacterial vaccination. (October 2015)

• Record Type: Journal Article
• Authors: Barnett, Timothy C; Lim, Jin Yan; Soderholm, Amelia T; Rivera-Hernandez, Tania; West, Nicholas P; Walker, Mark J
• Is Part Of: Current opinion in immunology. Volume 36(2015)
• Page Start: 1
• Page End: 7
• Publication Date: 2015-10
• Subjects: Immunology -- Periodicals; Allergy -- Periodicals; Immunology -- Abstracts -- Periodicals; Allergy -- Abstracts -- Periodicals; 616.079
• DOI: 10.1016/j.coi.2015.04.002
• Languages: English
• ISSNs: 0952-7915

Abstract

Highlights: Vaccines protect against several important human bacterial pathogens. Bacterial vaccine escape mutants limit coverage and effectiveness. Improvements in design may improve future vaccines. Abstract : Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis . These vaccines are generally considered a successful public health measure and are effective at controlling disease symptoms and/or burden. However, a troubling consequence of recent vaccination programs has been the selection of vaccine escape mutants, whereby the pathogen displays a different repertoire of immune targets than those represented in the vaccine formulation. To address these issues of antigenic variation and bacterial evolution, continued and sustained efforts in epidemiological surveillance, vaccine development/formulation research, and understanding of the host–pathogen interaction are required.