A Concise Synthesis of Potential COX Inhibitor BRL‐37959 and Analogs Involving Bismuth(III) Catalyzed Friedel−Crafts Acylation. Issue 12 (22nd November 2018)

• Record Type: Journal Article
• Authors: Ahmed, Shamsul Arefin; Hinz, Damon J.; Jellen, Marcus J.; Hossain, M. Mahmun
• Is Part Of: Chemistry & biodiversity. Volume 15:Issue 12(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-22
• Subjects: NSAID -- benzofuran -- benzoylation -- bismuth(III) trifluoromethanesulfonate -- synthesis design; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201800334
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL‐37959, which is believed to be a potent nonsteroidal anti‐inflammatory drug (NSAID). The four‐step synthesis greatly increased the efficiency of compound production from commercially available salicylaldehydes. The synthesis involved an optimized, bismuth(III) trifluoromethanesulfonate catalyzed benzoylation of a benzofuran ring. Abstract :