Cover Feature: A Photoenzymatic NADH Regeneration System (ChemBioChem 22/2018). (31st October 2018)

• Record Type: Journal Article
• Authors: Höfler, Georg T.; Fernández‐Fueyo, Elena; Pesic, Milja; Younes, Sabry H.; Choi, Eun‐Gyu; Kim, Yong H.; Urlacher, Vlada B.; Arends, Isabel W. C. E.; Hollmann, Frank
• Is Part Of: Chembiochem. Volume 19:Number 22(2018)
• Page Start: 2322
• Page End: 2322
• Publication Date: 2018-10-31
• Subjects: biocatalysis -- enantioselectivity -- ketones -- photochemistry -- reduction; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201800654
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture shows the concept of photoenzymatic regeneration of NADH from its oxidised form (NAD + ) by combining deazaflavin photocatalysts with a putidadoxin reductase (PDR). The photoexcited deazaflavin mediates electron transfer from a sacrificial electron donor to the NADH regeneration enzyme (PDR). The latter then selectively reduces NAD + to 1, 4‐NADH, which in turn can be used, for example, for the stereoselective reduction of carbonyl groups into alcohols. More information can be found in the full paper by F. Hollmann et al. on page 2344 in Issue 22, 2018 (DOI: 10.1002/cbic.201800530 ).