Transversal dose distribution optimization for laser-accelerated proton beam medical applications by means of Geant4. (October 2018)

• Record Type: Journal Article
• Authors: Milluzzo, G.; Pipek, J.; Amico, A.G.; Cirrone, G.A.P.; Cuttone, G.; Korn, G.; Larosa, G.; Leanza, R.; Margarone, D.; Petringa, G.; Russo, A.; Schillaci, F.; Scuderi, V.; Romano, F.
• Is Part Of: Physica medica. Volume 54(2018)
• Page Start: 166
• Page End: 172
• Publication Date: 2018-10
• Subjects: Laser-driven ions -- ELIMED beam line -- Geant4 -- Medical applications -- Transversal dose distributions; Medical physics -- Periodicals; Biophysics -- Periodicals; Biophysics -- Periodicals; Imagerie médicale -- Périodiques; Radiothérapie -- Périodiques; Rayons X -- Sécurité -- Mesures -- Périodiques; Physique -- Périodiques; Médecine -- Périodiques; 610.153
• DOI: 10.1016/j.ejmp.2018.07.008
• Languages: English
• ISSNs: 1120-1797

Abstract

Highlights: Laser-driven beams as alternative source for hadrontherapy applications. Monte Carlo simulations of the ELIMED beam line for optically accelerated beams. Spatial dose distributions optimization at the irradiation point. Calculation of dose delivered per shot for energies of clinical relevance. Abstract: The main purpose of this paper is to quantitatively study the possibility of delivering dose distributions of clinical relevance with laser-driven proton beams. A Monte Carlo application has been developed with the Geant4 toolkit, simulating the ELIMED (MEDical and multidisciplinary application at ELI-Beamlines) transport and dosimetry beam line which is being currently installed at the ELI-Beamlines in Prague (CZ). The beam line will be used to perform irradiations for multidisciplinary studies, with the purpose of demonstrating the possible use of optically accelerated ion beams for therapeutic purposes. The ELIMED Geant4-based application, already validated against reference transport codes, accurately simulates each single element of the beam line, necessary to collect the accelerated beams and to select them in energy. Transversal dose distributions at the irradiation point have been studied and optimized to try to quantitatively answer the question if such kind of beam lines, and specifically the systems developed for ELIMED in Prague, will be actually able to transport ion beams not only for multidisciplinary applications, such as pitcher-catcher nuclear reactions (e.g. neutrons), PIXE analysis for cultural heritage and space radiation, but also for delivering dose patterns of clinical relevance in a future perspective of possible medical applications.