Super‐quenched Molecular Probe Based on Aggregation‐Induced Emission and Photoinduced Electron Transfer Mechanisms for Formaldehyde Detection in Human Serum. Issue 11 (17th May 2018)

• Record Type: Journal Article
• Authors: Yang, Haitao; Wang, Fujia; Zheng, Jilin; Lin, Hao; Liu, Bin; Tang, Yi‐Da; Zhang, Chong‐Jing
• Is Part Of: Chemistry, an Asian journal. Volume 13:Issue 11(2018)
• Page Start: 1432
• Page End: 1437
• Publication Date: 2018-05-17
• Subjects: aggregation-induced emission -- AIEgen -- bioimaging -- formaldehyde -- light-up probe; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201800530
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Energy transfer between fluorescent dyes and quenchers is widely used in the design of light‐up probes. Although dual quenchers are more effective in offering lower background signals and higher turn‐on ratios than one quencher, such probes are less explored in practice as they require both quenchers to be within the proximity of the fluorescent core. In this contribution, we utilized intramolecular motion and photoinduced electron transfer (PET) as quenching mechanisms to build super‐quenched light‐up probes based on fluorogens with aggregation‐induced emission. The optimized light‐up probe possesses negligible background and is able to detect not only free formaldehyde (FA) but also polymeric FA, with an unprecedented turn‐on ratio of >4900. We envision that this novel dual quenching strategy will help to develop various light‐up probes for analyte sensing. Abstract : Two is better than one : A strategy to dually quench AIEgens based on photoinduced electron transfer (distance‐dependent quencher, DDQ) and intramolecular motion fine‐tuned by a water‐soluble group (WSG) was developed. Using this strategy, a light‐up probe to detect free and polymeric formaldehyde with a turn‐on ratio of >4900 was prepared.