Back Cover: A Regio‐ and Diastereoselective Anodic Aryl–Aryl Coupling in the Biomimetic Total Synthesis of (−)‐Thebaine (Angew. Chem. Int. Ed. 34/2018). Issue 34 (21st June 2018)

• Record Type: Journal Article
• Authors: Lipp, Alexander; Ferenc, Dorota; Gütz, Christoph; Geffe, Mario; Vierengel, Nina; Schollmeyer, Dieter; Schäfer, Hans J.; Waldvogel, Siegfried R.; Opatz, Till
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 34(2018)
• Page Start: 11080
• Page End: 11080
• Publication Date: 2018-06-21
• Subjects: alkaloids -- biomimetic synthesis -- electrochemistry -- morphine -- thebaine; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201806821
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Enforcement of selectivity through a combination of electrochemistry and substrate design enabled the biomimetic synthesis of the economically important opium alkaloid (−)‐thebaine. In their Communication on page 11055 ff., T. Opatz and co‐workers present a regio‐ and diastereoselective anodic coupling of 3′, 4′, 5′‐trioxygenated laudanosine derivatives, thereby helping to overcome a long‐standing electrosynthetic challenge. Graphic edited by L. Großmann (Mainz).