Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation. (5th February 2016)

• Record Type: Journal Article
• Authors: Bertalovitz, Alexander C.; Pau, Milly S.; Gao, Shujuan; Malbon, Craig C.; Wang, Hsien-yu
• Is Part Of: Journal of molecular signaling. Volume 11(2016)
• Publication Date: 2016-02-05
• Subjects: Frizzled -- Frizzled-4 -- carboxy-terminus -- helix VIII -- Dishevelled -- Norrin; Cellular signal transduction -- Periodicals; 571.74
• DOI: 10.5334/1750-2187-11-1
• Languages: English
• ISSNs: 1750-2187

Abstract

The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.