Altered serum profile of the interleukin-22 system in inflammatory bowel disease. (December 2020)

• Record Type: Journal Article
• Authors: Sakemi, Ryosuke; Mitsuyama, Keiichi; Morita, Masaru; Yoshioka, Shinichiro; Kuwaki, Kotaro; Tokuyasu, Hidenori; Fukunaga, Shuhei; Mori, Atsushi; Araki, Toshihiro; Yoshimura, Tetsuhiro; Yamasaki, Hiroshi; Tsuruta, Kozo; Morita, Taku; Yamasaki, Sayo; Mizoguchi, Atsushi; Sou, Suketo; Torimura, Takuji
• Is Part Of: Cytokine. Volume 136(2020)
• Publication Date: 2020-12
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2020.155264
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Serum IL-22 was lower in patients with inflammatory bowel disease than in controls. The decrease in IL-22 was more dramatic in Crohn's disease than ulcerative colitis. Serum IL-22BP was lower in inflammatory bowel disease patients than in controls. IL-22/IL-22BP ratios were higher in ulcerative colitis patients than in controls. Albumin and CRP levels were correlated with IL-22BP (inversely) and IL-22/IL-22BP. Abstract: Background and Aim: Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. Methods: Blood samples from 92 healthy subjects, 98 patients with ulcerative colitis (UC), and 105 patients with Crohn's disease (CD) were analyzed for serum levels of IL-22, IL-22BP, human β-defensin 2 (hBD-2), and serum inflammatory parameters. Disease activity was assessed by the partial Mayo score and Harvey-Bradshaw index for UC and CD, respectively. Results: Serum IL-22 level was lower in UC (P < 0.001) and CD (P < 0.001) vs control and its decrease was more pronounced in CD than in UC (P = 0.019). Serum IL-22BP level was lower in UC (P < 0.001) and CD (P < 0.001) vs control and correlated with inflammatory parameters (albumin and C-reactive protein (CRP) in UC; hemoglobin, albumin, and CRP in CD). Serum IL-22/IL-22BP ratios were higher in UC (P = 0.009) vs control and correlated with inflammatory parameters (albumin and CRP). Serum hBD-2 level was higher only in CD (P = 0.015) but did not correlate with serum IL-22 levels, IL-22BP levels, IL-22/IL-22BP ratios, or inflammatory parameters. Conclusions: Dysregulation of the IL-22 system in the blood may play a role in the pathogenesis of IBD. Further studies are needed to understand the pathogenic and clinical significance of the blood IL-22 system in IBD.