Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage. (October 2020)

• Record Type: Journal Article
• Authors: Genc, Sila; Malpas, Charles B.; Gulenc, Alisha; Sciberras, Emma; Efron, Daryl; Silk, Timothy J.; Seal, Marc L.
• Is Part Of: Developmental cognitive neuroscience. Volume 45(2020)
• Publication Date: 2020-10
• Subjects: ADHD attention-deficit/hyperactivity disorder -- CCG cingulum cingulate gyrus -- CCH cingulum hippocampus -- CSD constrained spherical deconvolution -- CST cortico-spinal tract -- FA fractional anisotropy -- FBA fixel-based analysis -- FC fibre cross-section -- FD fibre density -- FDC fibre density and cross-section -- FOD fibre orientation distribution -- Fmajor forceps major -- Fminor forceps minor -- Fx fornix -- IFOF inferior fronto-occipital fasciculus -- ILF inferior longitudinal fasciculus -- MRI magnetic resonance imaging -- NICAP Neuroimaging of the Children's Attention Project -- PDS pubertal development scale -- SEIFA Socio-Economic Indexes for Areas -- SES socio-economic status -- SLF superior longitudinal fasciculus -- UF uncinate fasciculus; White matter -- Longitudinal -- Fixel-based analysis -- Puberty -- Fibre density -- Fibre morphology; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2020.100853
• Languages: English
• ISSNs: 1878-9293

Abstract

Highlights: Fibre properties derived from fixel-based analysis are sensitive to development. Age-related patterns are consistent with previous diffusion tensor studies. Pubertal stage correlates with fibre density and morphology in the right SLF. Pubertal stage correlates with fibre morphology in the right ILF. Pubertal progression interacts with age for longitudinal fibre density changes. Abstract: The pubertal period involves dynamic white matter development. This period also corresponds with rapid gains in higher cognitive functions including attention, as well as increased risk of developing mental health difficulties. This longitudinal study comprised children aged 9–13 years (n = 130). Diffusion magnetic resonance imaging (dMRI) data were acquired (b = 2800s/mm 2, 60 directions) at two time-points. We derived measures of fibre density and morphology using the fixel-based analysis framework and performed a tract-based mixed-effects modelling analysis to understand patterns of white matter development with respect to age, sex, pubertal stage, and the change in pubertal stage. We observed significant increases in apparent fibre density across a large number of white matter pathways, including major association and commissural pathways. We observed a linear relationship between pubertal stage and fibre density and morphology in the right superior longitudinal fasciculus, and fibre morphology in the right inferior longitudinal fasciculus. Finally, we report a significant interaction between the change in pubertal stage and age in the development of fibre density, for left-lateralised association tracts. Overall, white matter development across ages 9–13 years involves the expansion of major white matter fibre pathways, with key association pathways linked with pubertal stage.