Cribriform pattern does not have a significant impact in Gleason Score ≥7/ISUP Grade ≥2 prostate cancers submitted to radical prostatectomy. Issue 38 (18th September 2020)

• Record Type: Journal Article
• Authors: Flammia, Simone; Frisenda, Marco; Maggi, Martina; Magliocca, Fabio Massimo; Ciardi, Antonio; Panebianco, Valeria; De Berardinis, Ettore; Salciccia, Stefano; Di Pierro, Giovanni Battista; Gentilucci, Alessandro; Del Giudice, Francesco; Busetto, Gian Maria; Gallucci, Michele; Sciarra, Alessandro
• Other Names: Lucarelli. Giuseppe section editor.
• Is Part Of: Medicine. Volume 99:Issue 38(2020)
• Publication Date: 2020-09-18
• Subjects: prostatic neoplasm -- cribriform -- radical prostatectomy; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000022156
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Introduction: The aim of this study was to correlate cribriform pattern (CP) with other parameters in a large prospective series of Gleason score ≥7/ISUP grade ≥2 prostate cancer (PC) cases undergoing radical prostatectomy (RP). Methods: This is a prospective single-center study on 210 consecutive patients. Gleason pattern 4 and individual tumor growth patterns determination were performed either in biopsy or in surgical specimens for all patients. Results: At multiparametric magnetic resonance, a higher percentage of PI-RADS 5 was associated to CP (53.3% vs 17.7%, P = .038). CP was significantly and inversely ( r = −0.261; P = .001) correlated with perineural invasion (PNI) but not with other pathological parameters. Kaplan-Meier analysis showed that mean biochemical (Bp) and radiological (Rp) progression-free survival were similar (Bp = χ 2 0.906; P = .341; Rp = χ 2 1.880; P = .170) independently to CP. In PNI positive cases, Bp-free survival was higher ( χ 2 = 3.617; P = .057) in cases without CP. Conclusions: In a homogeneous population excluding ISUP 1 cases, CP showed limited prognostic value. We first described an association with PNI and a prognostic value influenced by PNI status.