IOP and Optic Nerve Head Morphology during Scleral Lens Wear. Issue 9 (September 2020)

• Record Type: Journal Article
• Authors: Walker, Maria K.; Pardon, Laura P.; Redfern, Rachel; Patel, Nimesh
• Is Part Of: Optometry and vision science. Volume 97:Issue 9(2020)
• Publication Date: 2020-09
• Subjects: Optometry -- Periodicals; Physiological optics -- Periodicals; Vision disorders -- Periodicals; 617.7505
• DOI: 10.1097/OPX.0000000000001567
• Languages: English
• ISSNs: 1040-5488

Abstract

Abstract : SIGNIFICANCE: Scleral lenses (SLs) are increasing in scope, and understanding their ocular health impact is imperative. The unique fit of an SL raises concern that the landing zone causes compression of conjunctival tissue that can lead to resistance of aqueous humor outflow and increased intraocular pressure (IOP). PURPOSE: This study aimed to assess changes in optic nerve head morphology as an indirect assessment of IOP and evaluate other IOP assessment methods during SL wear. METHODS: Twenty-six healthy adults wore SL on one randomly selected eye for 6 hours, whereas the fellow eye served as a control. Global minimum rim width (optical coherence tomography) and IOP (Icare, Diaton) were measured at baseline, 2 and 6 hours after SL application, and again after SL removal. Central corneal thickness, anterior chamber depth, and fluid reservoir depth were monitored. RESULTS: Minimum rim width thinning was observed in the test (−8 μm; 95% confidence interval [CI], −11 to −6 μm) and control (−6 μm; 95% CI, −9 to −3 μm) eyes after 6 hours of SL wear ( P < .01), although the magnitude of thinning was not significantly greater in the lens-wearing eyes ( P = .09). Mean IOP (Icare) significantly increased +2 mmHg (95% CI, +1 to +3 mmHg) in the test eyes ( P = .002), with no change in the control eyes. Mean IOP changes with Diaton were +0.3 mmHg (95% CI, −0.9 to +3.2 mmHg) in the test eyes and +0.4 mmHg (95% CI, −0.8 to +1.7 mmHg) in the control eyes. However, Diaton tonometry showed poor within-subject variation and poor correlation with Icare. No clinically significant changes were observed in central corneal thickness or anterior chamber depth. CONCLUSIONS: This study suggests that SLs have a minimal effect on IOP homeostasis in the normal eye during SL wear and an insignificant impact on the optic nerve head morphology in healthy adult eyes.