5HTTLPR polymorphism and postpartum depression risk: A meta-analysis. Issue 39 (25th September 2020)

• Record Type: Journal Article
• Authors: Li, Jianming; Chen, Yongjun; Xiang, Qin; Xiang, Ju; Tang, Yonghong; Tang, Liang
• Other Names: Tu. Wen-Jun section editor.
• Is Part Of: Medicine. Volume 99:Issue 39(2020)
• Publication Date: 2020-09-25
• Subjects: 5-HTTLPR -- asian -- polymorphism -- postpartum depression; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000022319
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Objective: Postpartum depression (PPD) is an episode of major depressive disorder that affecting women of childbearing age. 5-HTTLPR is 1 of the most extensively investigated polymorphisms in PPD. However, the previous results were inconsistent and inclusive. Hence, we performed a meta-analysis to precisely evaluate the association between 5-HTTLPR polymorphism and PPD susceptibility. Methods: The studies were retrieved through databases including PubMed, web of science, EMASE, and CNKI. The odd ratios (ORs) and 95% confidence interval (CIs) were applied for evaluating the genetic association between 5-HTTLPR (L/S) polymorphism and PPD risk. Results: Six studies with 519 cases and 737 controls were enrolled in the present study. The frequencies of allelic (OR = 0.72, 95%CI = 0.60–0.85, P = .0001) and dominant (OR = 0.57, 95%CI = 0.44–0.73, P = .004) models of 5-HTTLPR polymorphism significantly decreased in patients with PPD than those in the healthy controls. Subgroup analysis based on ethnicity revealed that the allelic (OR = 0.71, 95%CI = 0.60–0.85, P = .0001) and dominant (OR = 0.51, 95%CI = 0.32–0.79, P = .003) models of 5-HTTLPR polymorphism were significantly associated with PPD risk in Asian population ( P > .05). No evidence was observed between the recessive model of 5-HTTLPR polymorphism and PPD risk ( P > .05). Conclusions: The allelic and dominant models of 5-HTTLPR polymorphism might be protective factors for PPD. To confirm these results, larger number of association studies or multicenter case–control studies are necessary in the future. Abstract : Supplemental Digital Content is available in the text