Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV. (1st September 2020)

• Record Type: Journal Article
• Authors: Seaman, Shanti M.; Van Pilsum Rasmussen, Sarah E.; Nguyen, Anh Q.; Halpern, Samantha E.; You, Susan; Waldram, Madeleine M.; Anjum, Saad K.; Bowring, Mary Grace; Muzaale, Abimereki D.; Ostrander, Darin B.; Brown, Diane; Massie, Allan B.; Tobian, Aaron A.R.; Henderson, Macey L.; Fletcher, Faith E.; Smith, Burke; Chao, Ada; Gorupati, Nishita; Prakash, Katya; Aslam, Saima; Lee, Dong H.; Kirchner, Varvara; Pruett, Timothy L.; Haidar, Ghady; Hughes, Kailey; Malinis, Maricar; Trinh, Sonya; Segev, Dorry L.; Sugarman, Jeremy; Durand, Christine M.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 85:Number 1(2020)
• Publication Date: 2020-09-01
• Subjects: transplantation -- HOPE Act -- HIV+ organ donation -- HIV+ transplantation; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000002405
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Background: HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation. Methods: We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs. Results: Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D− organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01). Conclusions: Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience. Abstract : Supplemental Digital Content is Available in the Text.