Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis. (2nd January 2016)

• Record Type: Journal Article
• Authors: Hermans, L. E.; Oosterheert, J. J.; Kampschreur, L. M.; Ossewaarde-van Norel, J.; Dekkers, J.; Rothova, A.; de Groot-Mijnes, J. D. F.
• Is Part Of: Ocular immunology and inflammation. Volume 24:Number 1(2016)
• Page Start: 77
• Page End: 80
• Publication Date: 2016-01-02
• Subjects: Aqueous humor analysis -- Coxiella burnetii -- infection -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2014.925123
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Purpose : Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii -seropositive patients with idiopathic uveitis. Methods : From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii -seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results : Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions : Uveitis due to an intraocular infection with C. burnetii is unlikely.