An anion receptor that facilitates transmembrane proton–anion symport by deprotonating its sulfonamide N–H proton. Issue 73 (28th August 2018)

• Record Type: Journal Article
• Authors: Shinde, Sopan Valiba; Talukdar, Pinaki
• Is Part Of: Chemical communications. Volume 54:Issue 73(2018)
• Page Start: 10351
• Page End: 10354
• Publication Date: 2018-08-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc04044c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Indole-based amide-sulfonamide derivatives were synthesized. The X-ray crystal structure and chloride binding studies in solution showed a 1 : 1 stoichiometry. The ion transport study indicated the proton–anion symport across the lipid bilayer membrane. Abstract : Indole-based amide-sulfonamide derivatives were synthesized. The X-ray crystal structure and chloride binding studies in solution showed a 1 : 1 stoichiometry. The ion transport efficiency directly correlated to the p K a of the sulfonamide N–H protons. The mechanistic study indicated proton–anion symport across the lipid bilayer membrane.