Autophagy in cancer: Recent advances and future directions. (November 2020)

• Record Type: Journal Article
• Authors: Ishaq, Mohd; Ojha, Rani; Sharma, Aditya P.; Singh, Shrawan K.
• Is Part Of: Seminars in cancer biology. Volume 66(2021)
• Page Start: 171
• Page End: 181
• Publication Date: 2020-11
• Subjects: Autophagy -- Cancer -- Therapy -- Tumor immunity -- Resistance; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2020.03.010
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Autophagy is being explored as a potential therapeutic target for enhancing the cytotoxic effects of chemotherapeutic regimens in various malignancies. Autophagy plays a very important role in cancer pathogenesis. Here, we discuss the updates on the modulation of autophagy via dynamic interactions with different organelles and the exploitation of selective autophagy for exploring therapeutic strategies. We further discuss the role of autophagy inhibitors in cancer preclinical and clinical trials, novel autophagy inhibitors, and challenges likely to be faced by clinicians while inducting autophagy modulators in clinical practice.