Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. (3rd July 2018)

• Record Type: Journal Article
• Authors: Šplíchal, Zbyněk; Zlámal, Filip; Máchal, Jan; Lipková, Jolana; Pavlová, Tereza; Hodická, Zuzana; Ventruba, Pavel; Vašků, Anna; Bienertová-Vašků, Julie
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 31:Number 13(2018)
• Page Start: 1689
• Page End: 1695
• Publication Date: 2018-07-03
• Subjects: Omentin-1 -- adipokine -- preterm birth -- Val109Asp polymorphism -- PPROM; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2017.1323530
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs). Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with ( n = 16) and without ( n = 14) preterm premature rupture of membranes (PPROM). Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period ( p = .015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM ( p = .990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established. Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.