Selective Synthesis of Primary Amines from Nitriles under Hydrogenation Conditions. Issue 8 (12th March 2018)

• Record Type: Journal Article
• Authors: Yoshimura, Masatoshi; Komatsu, Akira; Niimura, Masaru; Takagi, Yukio; Takahashi, Tohru; Ueda, Shun; Ichikawa, Tomohiro; Kobayashi, Yutaka; Okami, Hiroki; Hattori, Tomohiro; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 8(2018)
• Page Start: 1726
• Page End: 1732
• Publication Date: 2018-03-12
• Subjects: amines -- chemoselectivity -- gold -- heterogeneous catalysis -- hydrogenation -- nitriles -- palladium; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800102
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The hydrogenation of aliphatic nitriles over Pd/C, Pd/Al2 O3, and Pd−Au/Al2 O3 catalysts were evaluated for the selective hydrogenation of aliphatic nitriles to the corresponding primary amines. The highest selectivity (>99%) toward primary amines was achieved when the reaction was carried out in acetic acid using 10 mol% of 25% Pd‐5% Au/Al2 O3 under relatively low hydrogen pressure (0.8 MPa). Characterization of the catalysts by XRD, CO adsorption experiments, and EXAFS revealed that the excellent selectivity of 25% Pd‐5% Au/Al2 O3 toward the synthesis of primary amines is determined by the electronic properties and/or the surface structure resulting from alloying Pd with Au. Abstract :