Choroidal Infiltration as First Clinical Manifestation of T-cell Large Granular Lymphocyte (T-LGL) Leukemia. (2nd October 2020)

• Record Type: Journal Article
• Authors: Sarny, Stephanie; Beham-Schmid, Christine; El-Shabrawi, Yosuf
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 7(2020)
• Page Start: 1133
• Page End: 1135
• Publication Date: 2020-10-02
• Subjects: Choroidal biopsy -- choroiditis -- cyclophosphamide -- T-LGL leukemia -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1645186
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To report of a 55-year-old woman suffering from choroidal infiltrates as a first clinical manifestation of T-LGL leukemia. Methods : Retrospective case report. Results : A healthy woman presented with photophobia in both eyes since 1 month. She showed a panuveitis with anterior chamber as well as vitreous cells, creamy-white choroidal lesions in both eyes and a cystoid macular edema in the left eye. Lab testing showed only a moderate lymphocytosis, all other tests, including a pars plana vitrectomy and an anterior chamber tap, were negative. Due to the persistent lymphocytosis, she was referred to the oncologist. A biopsy of the bone marrow revealed T-LGL leukemia. A subsequent biopsy of the choroid showed an infiltration of T-LGL and therefore systemic therapy with cyclophosphamide was started. Conclusions : This is a very rare case describing an involvement of the choroid in T-LGL leukemia.