Onco-IP3Rs Feed Cancerous Cravings for Mitochondrial Ca2+. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Bultynck, Geert
• Is Part Of: Trends in biochemical sciences. Volume 41:Issue 5(2016)
• Page Start: 390
• Page End: 393
• Publication Date: 2016-05
• Subjects: inositol 1, 4, 5-trisphosphate receptors -- ITPR -- Ca2+ -- mitochondria -- tumor metabolism; Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2016.03.006
• Languages: English
• ISSNs: 0968-0004

Abstract

Abstract : The uncontrolled proliferation of cancer cells requires functional mitochondrial metabolism, which uses Ca 2+ as a cofactor. IP3 receptors (IP3 Rs) from endoplasmic reticulum (ER) Ca 2+ stores provide the supply of Ca 2+ to mitochondria. A new study by Cardenas et al. shows that, in contrast to normal cells, cancer cells critically depend on ER–mitochondrial Ca 2+ fluxes for their survival by sustaining the production of mitochondrial substrates used for nucleotide biosynthesis and proliferation.