Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis. Issue 2 (9th January 2018)

• Record Type: Journal Article
• Authors: Mikulecky, Pavel; Andreeva, Elena; Amara, Patricia; Weissenhorn, Winfried; Nicolet, Yvain; Macheboeuf, Pauline
• Is Part Of: FEBS letters. Volume 592:Issue 2(2018)
• Page Start: 199
• Page End: 208
• Publication Date: 2018-01-09
• Subjects: antiviral activity -- innate immunity -- radical SAM -- viperin; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12941
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses. Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis. We postulate that the radical modification of these two molecules by viperin might lead to defects in cholesterol synthesis, thereby affecting the composition of lipid rafts and subsequent enveloped virus budding. Abstract :