Cellulose nanocrystals as carriers in medicine and their toxicities: A review. (1st February 2018) - Seabra, Amedea B.
Graphical abstract: Highlights: The surface modification of cellulose nanocrystals as drug delivery system is presented. The nanotoxicity and Ecotoxicology of nanocellulose-based systems are discussed. Commercial products and patents on cellulose nanocrystals are presented. Abstract: Cellulose nanocrystals (CNCs) are crystalline nanoparticles that present myriad applications. CNCs are produced from a variety of renewable sources, and they can be chemically modified. Although there are promising perspectives for introducing CNCs into pharmaceutical formulations, prior to achieving commercial products the influence of many parameters such as extraction and toxicity of the resulting products must be revealed. Since there is great physicochemical flexibility in the steps of obtaining and conjugating CNCs, there are uncountable and complex outcomes from the interactions of those parameters. We present a discussion that helps to unveil the whole panorama on the use of CNCs as drug delivery systems. The methods of producing CNCs are correlated to the resulting nanotoxicity from the cellular to organism level. This review points to relevant concerns that must be overcome to attain safe use of these nanostructures. We also discuss the patents and commercially available products based on CNCs.