Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant?. (5th October 2017)

• Record Type: Journal Article
• Authors: Bolden, Ashley L.; Rochester, Johanna R.; Kwiatkowski, Carol F.
• Is Part Of: Toxicology letters. Volume 280(2017)
• Page Start: 181
• Page End: 189
• Publication Date: 2017-10-05
• Subjects: 17β-HSD 17β-hydroxysteroid dehydrogenase -- ACh acetylcholine -- AChE acetylcholinesterase -- CA1 region 1 of hippocampus proper -- CAT catalase -- ER estrogen receptor -- fEPSP field excitatory postsynaptic potentials -- GPx glutathione peroxidase -- HFS high frequency stimulation -- HSP70 heat shock protein -- Ig immunoglobin -- IL interleukin -- LTD long-term depression -- LTP long-term potentiation -- MDA malondialdehyde -- MCH mean corpuscular haemoglobin -- MWM Morris water maze test -- NR2B N-methyl d-aspartate receptor subtype 2B -- PR progesterone receptor -- OHAT Office of Health Assessment and Translation -- PSD95 postsynaptic density protein 95 -- ROS reactive oxygen species -- SOD superoxide dismutase -- SYP synaptophysin -- WHO World Health Organization; Melamine -- Cyromazine -- Neurological -- Reproduction -- Growth -- Scoping review; Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2017.07.893
• Languages: English
• ISSNs: 0378-4274

Abstract

Abstract: Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and pets. This resulted in a large amount of published primary studies and reviews of the impacts of melamine exposure on kidney function. However, a growing body of literature suggests that melamine may have impacts beyond renal dysfunction. We conducted a scoping review of this literature which yielded more than 40 studies with human, animal, and in vitro findings. Neurological impacts, reproductive function, and anthropometric outcomes were identified as possible candidates for systematic review based on evidence stream and replication of endpoints. The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure.