Phytotoxic, antibacterial, and antioxidant activities of mycotoxins and other metabolites from Trichoderma sp. Issue 23 (2nd December 2017)

• Record Type: Journal Article
• Authors: Zhang, Ju-cheng; Chen, Guang-Yi; Li, Xiao-Zhan; Hu, Ming; Wang, Bang-Yan; Ruan, Bao-Hui; Zhou, Hao; Zhao, Li-Xing; Zhou, Jun; Ding, Zhong-Tao; Yang, Ya-Bin
• Is Part Of: Natural product research. Volume 31:Issue 23(2017)
• Page Start: 2745
• Page End: 2752
• Publication Date: 2017-12-02
• Subjects: Trichoderma sp. -- metabolite -- phytotoxicity -- DPPH radical-scavenging activity -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1295235
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new natural mycotoxin was isolated from the fermentation broth of Trichoderma sp. Jing-8 and the structure was determined as alternariol 1′-hydroxy-9-methyl ether (1 ), together with twelve known compounds. The structures were elucidated on the basis of their 1D, 2D NMR spectra and mass spectrometric data. Compounds 1, 8 and 9 indicated inhibitions against germination of the seeds of cabbage with MICs < 3 μg/mL. The compound 1 showed the antibacterial activity against Bacillus subtilis and Staphylococcus aureus with MICs at 64 μg/mL. Compound 1 and 3 showed significant DPPH radical-scavenging activities with IC50 at 12 μg/mL, respectively. The OH at C-1′ in compound 1 decreased the cytotoxicity of these mycotoxins. A primary structure–activity relationship about the alternariol derivatives was discussed. Compounds 2 –7 and 8 were the first time to be isolated from the Trichoderma . Abstract :