Serum ferritin as an activity marker for granulamotosis with polyangiitis. (1st January 2017)

• Record Type: Journal Article
• Authors: Kucuk, Hamit; Varan, Ozkan; Goker, Berna; Bitik, Berivan; Ozturk, Mehmet Akif; Haznedaroglu, Seminur; Tufan, Abdurrahman
• Is Part Of: Renal failure. Volume 39:Number 1(2017)
• Page Start: 566
• Page End: 569
• Publication Date: 2017-01-01
• Subjects: Granulomatosis with polyangiitis -- ferritin -- biomarker -- activity -- vasculitis; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.1080/0886022X.2017.1349675
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Background: Serum ferritin correlates well with the activities of systemic lupus erythematosus (SLE) and dermatomyositis, but it has not been previously studied in patients with vasculitis. Methods: Medical records of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) patients with at least six months of regular follow-up were evaluated. The activity of GPA was assessed with Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Serum ferritin and other acute phase markers were measured at initial presentation. Results: Serum ferritin levels were found to be the highest in GPA patients with alveolar hemorrhage, median (IQR) 1041 (1281) μg/L. Patients with renal disease also had high levels of ferritin and it was correlated with concurrent glomerular filtration rate ( r = −0.65, p < .001). Serum ferritin is also correlated well with the BVAS/WG scores ( r = 0.79, p < .001). Conclusions: Measurement of serum ferritin might help in assessing disease activity of GPA.