Melanoma metastases caught in the AKT. (3rd March 2016)

• Record Type: Journal Article
• Authors: Kircher, David A.; Arave, Rowan A.; Cho, Joseph H.; Holmen, Sheri L.
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 2(2016)
• Publication Date: 2016-03-03
• Subjects: AKT -- Melanoma -- Metastases -- Mouse -- Pten; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1128516
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context.