Efficacy and Safety of Carbetocin Given as an Intravenous Bolus Compared With Short Infusion for Caesarean Section: Double-blind, Double-dummy, Randomized Controlled Noninferiority Trial. Issue 4 (December 2017)

• Record Type: Journal Article
• Authors: Dell-Kuster, S.; Hoesli, I.; Lapaire, O.; Seeberger, E.; Steiner, L.A.; Bucher, H.C.; Girard, T.
• Is Part Of: Obstetric anesthesia digest. Volume 37:Issue 4(2017:Dec.)
• Publication Date: 2017-12
• Subjects: Obstetric Hemorrhage -- Obstetric Complications -- Pharmacology; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000527031.55499.e4
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( Br J Anaesth . 2017;118(5):772–780) Uterotonic drugs, such as oxytocin, are given after cesarean section (CS) to help maintain uterine tone. It is recommended that these drugs be administered as a short, rapid infusion rather than a bolus, so as to minimize adverse side effects. However, there are no trial designs that show noninferiority of uterine tone using a slower mode of drug administration. Carbetocin is a synthetic oxytocin analogue with the same mechanism of action and side effects as oxytocin but with a longer half-life. The authors of the present study investigated the efficacy of a 100 mcg carbetocin dose on uterine contractility administered as a short, rapid infusion compared to a slow manual injection.