Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis. Issue 12 (25th October 2017)

• Record Type: Journal Article
• Authors: Bonifacio, Massimiliano; Zanotti, Roberta; Guardalben, Emanuele; Mimiola, Elda; Scognamiglio, Francesca; Perbellini, Omar; De Matteis, Giovanna; Escribano, Luis; Bonadonna, Patrizia; Grigolato, Daniela; Bissoli, Sergio; Parisi, Alice; Zamò, Alberto; Ambrosetti, Achille; Rossini, Maurizio
• Is Part Of: Clinical case reports. Volume 5:Issue 12(2017)
• Page Start: 1988
• Page End: 1991
• Publication Date: 2017-10-25
• Subjects: Non‐hodgkin lymphoma -- osteolysis -- primary bone lymphoma -- systemic mastocytosis -- tryptase; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.1232
• Languages: English
• ISSNs: 2050-0904

Abstract

Key Clinical Message: Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized by low MC burden, should prompt investigations for an alternative explanation. Abstract : Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized by low MC burden, should prompt investigations for an alternative explanation.