From transcriptional complexity to cellular phenotypes: Lessons from yeast. Issue 12 (11th October 2017)

• Record Type: Journal Article
• Authors: Pelechano, Vicent
• Is Part Of: Yeast. Volume 34:Issue 12(2017:Dec.)
• Page Start: 475
• Page End: 482
• Publication Date: 2017-10-11
• Subjects: transcriptome -- mRNA isoforms -- alternative polyadenylation -- Transcription start site -- S. cerevisiae; Yeast -- Periodicals; Yeasts -- Periodicals; Yeasts -- genetics -- Periodicals; Electronic journals; 547
• DOI: 10.1002/yea.3277
• Languages: English
• ISSNs: 0749-503X

Abstract

Abstract: Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non‐coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine‐tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell‐to‐cell phenotypic variability. Copyright © 2017 John Wiley & Sons, Ltd. Abstract : In this review article, the author discusses how variations of the transcriptome can diversify the proteome and modulate the gene expression process. He presents multiple strategies to link molecular variations with divergent biological outcomes, and considers the relevance of transcriptional complexity for cell‐to‐cell variability.