11C-Meta-Hydroxyephedrine: A Promising PET Radiopharmaceutical for Imaging the Sympathetic Nervous System. (February 2015)

• Record Type: Journal Article
• Authors: Boschi, Stefano; Lodi, Filippo; Boschi, Laura; Nanni, Cristina; Chondrogiannis, Sotirios; Colletti, Patrick M.; Rubello, Domenico; Fanti, Stefano
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 2(2015)
• Publication Date: 2015-02
• Subjects: 11C-meta-hydroxyephedrine -- positron emission tomography -- PET -- CNS imaging -- cardiac imaging; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000512
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Dysfunction of the sympathetic nervous system underlies many cardiac diseases and can be assessed by molecular imaging using SPECT tracers as 123 I-metaiodobenzylguanidine ( 123 I-MIBG). The norepinephrine analog 11 C- meta -hydroxyephedrine (HED) has been used with PET to map the regional distribution of cardiac sympathetic neurons. Hydroxyephedrine is rapidly transported into sympathetic neurons by the norepinephrine transporter and stored in vesicles. This review describes the mechanism of action, radiosynthesis, and application of HED in the assessment of the cardiac sympathetic nervous system in heart failure, myocardial infarction, and arrhythmias. Noncardiac applications of HED in the clinical setting of sympathetic nervous system tumors and other emerging research applications are described.