Case Study: Diffuse Large B-Cell Lymphoma Arising in Ovarian Mature Cystic Teratoma. (September 2015)

• Record Type: Journal Article
• Authors: Maguire, Aoife; Castriciano, Giuseppa; Walker, Jan; Molloy, Karen; Quinn, Fiona; Osman, Nemer; Vandenberghe, Elisabeth; Jeffers, Michael; Gaffney, Eoin; Flavin, Richard
• Is Part Of: International journal of gynecological pathology. Volume 34:Number 5(2015:Sep.)
• Publication Date: 2015-09
• Subjects: Mature cystic teratoma -- Lymphoma -- Diffuse large B-cell lymphoma; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000172
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : We describe an unexpected finding of diffuse large B-cell lymphoma associated with mature cystic teratoma of the ovary. A 68-yr-old woman with a complex left ovarian cystic mass on imaging underwent bilateral salpingo-oophorectomy, lymphadenectomy, appendicectomy, and omentectomy. Histopathologic examination revealed nodules of malignant non-Hodgkin lymphoma within the teratoma. A diagnosis of diffuse large B-cell lymphoma, germinal center cell subtype by Hans criteria was made after immunostaining and molecular studies. The patient was treated with R-CHOP chemotherapy and remains disease-free at 14-mo follow-up.