A simple method for estimating in vitro air-tissue and in vivo blood-tissue partition coefficients. (February 2015) - Abraham, Michael H.
Abstract : Graphical abstract: Highlights: Air-to-tissue and blood-to-tissue partitions are estimated by LFERs. The LFERs are simple, transparent, and calculations are trivial. The LFERs apply to VOCs, to pesticides, to drugs and to common chemicals. Other environmentally important processes can also be studied. Abstract: A simple method is reported for the estimation of in vivo air-tissue partition coefficients of VOCs and of in vitro blood-tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-tissue and blood-tissue partitions.