Absence of mutagenic activity in the bacterial reverse mutation assay with pulegone and peppermint oil. (8th July 2020)

• Record Type: Journal Article
• Authors: Bastaki, Maria; Lu, Vivian; Aubanel, Michel; Bialk, Heidi; Choi, Christopher; Demyttenaere, Jan; Diop, Maodo Malick; Etter, Sylvain; Han, Xing; Harman, Christie L; Krammer, Gerhard; Schnabel, Jürgen; Wilson, Cody L; Taylor, Sean V
• Is Part Of: Toxicology research and application. Volume 4(2020)
• Publication Date: 2020-07-08
• Subjects: Ames assay -- mutagenicity -- pulegone -- peppermint oil -- bacterial reverse mutation -- OECD 471; Toxicology -- Periodicals; 571.9505
• DOI: 10.1177/2397847320938666
• Languages: English
• ISSNs: 2397-8473

Abstract

The essential oil of peppermint and one of its natural constituents, (R)-(+)-pulegone, are approved flavorings added to food worldwide. (R)-(+)-Pulegone and peppermint oil were tested separately in two independent bacterial reverse mutation assays according to Organisation for Economic Co-operation and Development Guideline 471. Both flavorings did not produce any evidence of mutagenicity up to cytotoxic concentrations in either the presence or the absence of exogenous metabolic activation.