RNA interference in glial cells for nerve injury treatment. (July 2020)

• Record Type: Journal Article
• Authors: Lin, Junquan; Jo, Seung Bin; Kim, Tae-Hyun; Kim, Hae-Won; Chew, Sing Yian
• Is Part Of: Journal of tissue engineering. Volume 11(2020)
• Publication Date: 2020-07
• Subjects: RNA interference -- central nervous system -- nerve injury -- drug delivery; Tissue engineering -- Periodicals; 612.028
• DOI: 10.1177/2041731420939224
• Languages: English
• ISSNs: 2041-7314

Abstract

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.