Visibility of focal liver lesions: Comparison between kupffer phase of CEUS with sonazoid and hepatobiliary phase of gadoxetic acid–enhanced MRI. Issue 9 (26th May 2017)

• Record Type: Journal Article
• Authors: Yang, Woo Young; Park, Hee Sun; Kim, Young Jun; Yu, Mi Hye; Jung, Sung Il; Jeon, Hae Jeong
• Is Part Of: Journal of clinical ultrasound. Volume 45:Issue 9(2017)
• Page Start: 542
• Page End: 550
• Publication Date: 2017-05-26
• Subjects: focal liver lesion -- contrast‐enhanced sonography -- sonazoid -- gadoxetic acid–enhanced MRI; Ultrasonics in medicine -- Periodicals; 616.07543
• DOI: 10.1002/jcu.22499
• Languages: English
• ISSNs: 0091-2751

Abstract

ABSTRACT: Background: To investigate the agreement between Kupffer phase of Sonazoid contrast‐enhanced sonography (CEUS) and hepatobiliary phase of gadoxetic acid–enhanced MRI in the evaluation of focal liver lesions (FLLs). Methods: One hundred fifty‐four FLLs in 154 patients who underwent both Sonazoid CEUS and gadoxetic acid–enhanced liver MRI were included in this retrospective study. FLL visibility on the Kupffer‐phase images was graded as one (invisible or isoenhancing), two (vaguely visible or vaguely hypoenhancing), or three (clearly visible or clearly hypoenhancing), and that on the hepatobiliary‐phase images of MRI was graded as one (invisible or hyper/isointense), two (vaguely visible or weakly hypointense), or three (clearly visible or strongly hypointense). Pairwise comparison of lesion visibility between the two modalities was performed, and intermodality agreement was assessed. Results: On Kupffer‐phase CEUS, 31 (20.1%) lesions were invisible, 17 (11.1%) were vaguely visible, and 106 (68.9%) were clearly visible. On the hepatobiliary‐phase MRI, 9 (5.9%) lesions were invisible, 45 (29.2%) were vaguely visible, and 100 (64.9%) were clearly visible. Overall, lesion visibility scores were not significantly different between the two modalities ( p = 0.121), but the visibility was significantly better on MRI in smaller lesions. Twenty‐eight lesions (18.2%) showed discrepancy in the visibility on CEUS and MRI, and most of the cases (89.7%) were lesions that were invisible on CEUS but visible on MRI. Conclusions: The overall visibility of FLLs was comparable between the Kupffer phase of Sonazoid‐CEUS and the hepatobiliary‐phase images of gadoxetic acid–enhanced MRI, with a discrepancy between the two modalities in 18% of the cases. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45 :542–550, 2017