Issues raised by the reference doses for perfluorooctane sulfonate and perfluorooctanoic acid. (August 2017)

• Record Type: Journal Article
• Authors: Dong, Zhaomin; Bahar, Md Mezbaul; Jit, Joytishna; Kennedy, Bruce; Priestly, Brian; Ng, Jack; Lamb, Dane; Liu, Yanju; Duan, Luchun; Naidu, Ravi
• Is Part Of: Environment international. Volume 105(2017)
• Page Start: 86
• Page End: 94
• Publication Date: 2017-08
• Subjects: PFOS -- PFOA -- Reference dose -- Toxicity -- Uncertainties; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2017.05.006
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: On 25th May 2016, the U.S. EPA released reference doses (RfDs) for Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) of 20 ng/kg/day, which were much more conservative than previous values. These RfDs rely on the choices of animal point of departure (PoD) and the toxicokinetics (TK) model. At this stage, considering that the human evidence is not strong enough for RfD determination, using animal data may be appropriate but with more uncertainties. In this article, the uncertainties concerning RfDs from the choices of PoD and TK models are addressed. Firstly, the candidate PoDs should include more critical endpoints (such as immunotoxicity), which may lead to lower RfDs. Secondly, the reliability of the adopted three-compartment TK model is compromised: the parameters are not non-biologically plausible; and this TK model was applied to simulate gestation and lactation exposures, while the two exposure scenarios were not actually included in the model structure. Graphical abstract: Highlights: Current human epidemiological data are not strong enough for RfD determination. More critical endpoints should be included as candidate PoDs. The utilised toxicokinetics model in RfD determination of PFOS/A should be improved.