Development of renal renin‐expressing cells does not involve PDGF‐B‐PDGFR‐β signaling. Issue 5 (24th October 2013)

• Record Type: Journal Article
• Authors: Neubauer, Bjoern; Machura, Katharina; Rupp, Verena; Tallquist, Michelle D.; Betsholtz, Christer; Sequeira‐Lopez, Maria Luisa S.; Ariel Gomez, R.; Wagner, Charlotte
• Is Part Of: Physiological reports. Volume 1:Issue 5(2013:Oct.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2013-10-24
• Subjects: Mural cells -- PDGF‐B -- PDGF‐β receptor -- pericyte -- renin; Physiology -- Periodicals; 571
• DOI: 10.1002/phy2.132
• Languages: English
• ISSNs: 2051-817X

Abstract

Abstract: Apart from their endocrine functions renin‐expressing cells play an important functional role as mural cells of the developing preglomerular arteriolar vessel tree in the kidney. The recruitment of renin‐expressing cells from the mesenchyme to the vessel wall is not well understood. Assuming that it may follow more general lines of pericyte recruitment to endothelial tubes we have now investigated the relevance of the platelet‐derived growth factor (PDGF)‐B‐PDGFR‐ β signaling pathway in this context. We studied renin expression in kidneys lacking PDGFR‐ β in these cells and in kidneys with reduced endothelial PDGF‐B expression. We found that expression of renin in the kidneys under normal and stimulated conditions was not different from wild‐type kidneys. As expected, PDGFR‐ β immunoreactivity was found in mesangial, adventitial and tubulo‐interstitial cells but not in renin‐expressing cells. These findings suggest that the PDGF‐B‐PDGFR‐ β signaling pathway is not essential for the recruitment of renin‐expressing cells to preglomerular vessel walls in the kidney. Abstract : e00132 Abstract : We studied the distribution of renin‐expressing cells in mouse kidneys in which the PDGF‐B‐PDGFR‐ β signaling had been knocked down in renin‐expressing cells or endothelial cells. Our findings suggest that this signaling pathway is not essential for the recruitment of renin‐expressing cells to preglomerular vessel walls in the kidney.