Cathepsin F of Teladorsagia circumcincta is a recently evolved cysteine protease. (October 2020)

• Record Type: Journal Article
• Authors: Sloan, Sarah; Jenvey, Caitlin; Cairns, Callum; Stear, Michael
• Is Part Of: Evolutionary bioinformatics online. Volume 16(2020)
• Publication Date: 2020-10
• Subjects: Cysteine protease -- cathepsin -- Teladorsagia circumcincta -- bioinformatics -- homology modeling -- gastrointestinal nematode; Bioinformatics -- Periodicals; Evolutionary computation -- Periodicals; Genetic programming (Computer science) -- Periodicals; Computational Biology; Evolution, Molecular; Bioinformatics; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 576.8
• DOI: 10.1177/1176934320962521
• Languages: English
• ISSNs: 1176-9343

Abstract

Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode Teladorsagia circumcincta, while its transcript is only detectable in L4 and adults. T. circumcincta cathepsin F is a recently evolved cysteine protease that does not fall clearly into either of the cathepsin L or F subfamilies. This protein exhibits characteristics of both cathepsins F and L, and its phylogenetic relationship to its closest homologs is distant, including proteins of closely related nematodes of the same subfamily.