Periprocedural platelet inhibition with cangrelor in P2Y12-inhibitor naïve patients with acute coronary syndromes — A matched-control pharmacodynamic comparison in real-world patients. (15th November 2016)

• Record Type: Journal Article
• Authors: Droppa, Michal; Spahn, Pascal; Takhgiriev, Khalid; Müller, Karin A.L.; Alboji, Ahmed; Straub, Andreas; Rath, Dominik; Jeong, Young-Hoon; Gawaz, Meinrad; Geisler, Tobias
• Is Part Of: International journal of cardiology. Volume 223(2016)
• Page Start: 848
• Page End: 851
• Publication Date: 2016-11-15
• Subjects: ACS acute coronary syndrome -- ADP adenosine diphosphate -- CAD coronary artery disease -- GFR glomerular filtration rate -- LV-EF left ventricular ejection fraction -- MEA multiple electrode aggregometry -- NSTE-ACS non-ST-elevation acute coronary syndrome -- NSTEMI non-ST-elevation myocardial infarction -- PCI percutaneous coronary intervention -- STEMI ST-elevation myocardial infarction -- TEG thromboelastography -- UA unstable angina pectoris; Cangrelor -- Acute coronary syndrome -- Platelet inhibition -- Multiple electrode aggregometry -- Thromboelastography; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.08.270
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Effective inhibition of platelet aggregation during PCI in high risk patients with ACS is of utmost importance. The new intravenous short acting P2Y12 -receptor inhibitor cangrelor is available for use in PCI-treated patients. We aimed to study platelet inhibition during treatment with cangrelor and transition phase with oral P2Y12 -receptor inhibitors in patients with acute coronary syndromes (ACS). Methods: Cangrelor was administered during PCI to 21 P2Y12 -inhibitor naïve patients with ACS. Patients received a loading dose of ticagrelor at the time of procedure or prasugrel 30 min before end of the cangrelor infusion. Platelet inhibition was measured by multiple electrode aggregometry (MEA) and thromboelastography (TEG), before and after PCI, immediately and 2 h after stopping the infusion. Platelet inhibition after PCI was compared to a matched cohort of patients treated with oral P2Y12 -inibitors only. Results: There was a significant reduction of platelet reactivity measured by MEA-ADP from 46.7 U to 17.9 U and by TEG MA ADP from 43.1 mm to 22.0 mm before infusion and after PCI respectively ( p < 0.001). There was also sustained platelet inhibition after stopping of cangrelor infusion and 2 h later. Significant higher platelet inhibition was observed at the end of PCI in comparison to control cohort without cangrelor (MEA 17.9 U vs. 54.2 U, p = 0.001). Conclusion: We demonstrate significantly improved platelet inhibition during PCI in ACS patients treated with cangrelor in comparison to early treatment with potent oral P2Y12 -inhibitors. Cangrelor should be considered for periprocedural treatment of high risk patients with acute coronary syndrome.