Chemo-enzymatic synthesis of new resveratrol-related dimers containing the benzo[b]furan framework and evaluation of their radical scavenger activities. Issue 20 (20th May 2015)

• Record Type: Journal Article
• Authors: Beneventi, Elisa; Conte, Silvia; Cramarossa, Maria Rita; Riva, Sergio; Forti, Luca
• Is Part Of: Tetrahedron. Volume 71:Issue 20(2015)
• Page Start: 3052
• Page End: 3058
• Publication Date: 2015-05-20
• Subjects: Resveratrol -- Laccase -- Biocatalysis -- Oxidation -- Benzo[b]furan; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2014.11.012
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The chemo-enzymatic synthesis and the evaluation of radical scavenger performance of resveratrol-related dimers with antioxidative power have been investigated. The dimeric compounds, containing the benzo[ b ]furan framework, were prepared via an oxidative dimerization catalyzed by a laccase from Trametes versicolor, followed by a treatment with the organic oxidant DDQ. This methodology can be useful for the synthesis of various 2, 3-diarylbenzo[ b ]furans derivates, a class of compound that exhibits a wide range of biological activities. Graphical abstract: