A prospective study of community-associated Clostridium difficile infection in Kuwait: Epidemiology and ribotypes. (October 2015)

• Record Type: Journal Article
• Authors: Jamal, Wafaa; Pauline, Eunice; Rotimi, Vincent
• Is Part Of: Anaerobe. Volume 35:Part B(2015)
• Page Start: 28
• Page End: 32
• Publication Date: 2015-10
• Subjects: Community-acquired -- Clostridium difficile infection -- Kuwait -- Ribotypes -- Epidemiology; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2015.06.006
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Clostridium difficile infection (CDI) is increasingly recognized as a significant community acquired pathogen that causes disease in the community. The aim of the study was to investigate prospectively the incidence of community-acquired-CDI (CA-CDI) in Kuwait. Of the 2584 patients with diarrhea, 16 (0.62%) were confirmed cases of CA-CDI. The other notable pathogens were Salmonella spp. (0.39%) and Campylobacter spp. (0.23%). The mean age was 39 years and the CDI was mild. Exposure to antibiotics in the previous 12 weeks, contact with infant aged <2 years and history of foreign travel was significantly associated with CA-CDI ( P < 0.001; P < 0.0001; P < 0.002, respectively). Detected PCR ribotypes were 139 (n = 4) and 014, 056, 070, 097 and 179 (each n = 2). CA-CDI in Kuwait is more likely to occur in younger age and associated with ribotype 139. CA-CDI is not a common problem in Kuwait however extra vigilance must be maintained to detect it in the community even without traditional predisposing factors. Highlights: To study incidence of community-acquired Clostridium difficile infection (CA-CDI) in Kuwait. Of the 2584 patients with diarrhea, 16 (0.62%) were confirmed cases of CA-CDI. Exposure to antibiotics was significantly associated with CA-CDI. Contact with infant aged <2 years was significantly associated with CA-CDI. The most common C . difficile ribotype belonged to the European PCR-Ribotype 139.