Effects of teriparatide on fusion rates in patients undergoing complex foot and ankle arthrodesis. Issue 7 (October 2020)

• Record Type: Journal Article
• Authors: Lee, Hee Seop; Park, Jung Ho; Suh, Dong Hun; Kim, Hak Jun; Koo, Bong Mo; Kim, Hak Kyu; Yang, Se Hyun; Choi, Gi Won
• Is Part Of: Foot and ankle surgery. Volume 26:Issue 7(2020)
• Page Start: 766
• Page End: 770
• Publication Date: 2020-10
• Subjects: Teriparatide -- Foot -- Ankle -- Arthrodesis -- Fusion -- Nonunion; Foot -- Surgery -- Periodicals; Ankle -- Surgery -- Periodicals; Ankle -- surgery -- Periodicals; Foot -- surgery -- Periodicals; Ankle -- Surgery; Foot -- Surgery; Periodicals; Electronic journals; 617.58
• DOI: 10.1016/j.fas.2019.10.002
• Languages: English
• ISSNs: 1268-7731

Abstract

Highlights: Teriparatide administration may improve fusion rates in patients with high-risk factors for nonunion after foot and ankle arthrodesis. The fusion rate was greater in the teriparatide treatment group than in the control group. There was no significant differences in the complication rates between the 2 groups. Abstract: Background: Here, we determined whether teriparatide treatment would increase fusion rates after foot and ankle arthrodesis by comparing treatment results between patients with high-risk factors for nonunion who received teriparatide against those who did not. Methods: We retrospectively reviewed 66 consecutive patients who underwent foot and ankle arthrodesis. The inclusion criterion was the presence of at least one of the following risk factors for nonunion after previous foot and ankle arthrodesis: deformity, bone defects, avascular necrosis, and nonunion. Sixteen patients were finally enrolled and divided into 2 groups: 8 patients received teriparatide treatment after fusion surgery (PTH group), and 8 patients did not (control group). Results: The fusion rate was significantly greater in the PTH group than in the control group (100% vs 50%). Four patients in the control group developed nonunion, 3 of whom underwent revision fusion; however, all patients received the teriparatide treatment after revision surgery and subsequently achieved union. No significant differences in demographics, fusion sites, and complication rates were found. Conclusion: Though the sample size was small, the current study suggests that teriparatide administration may improve fusion rates in patients with high-risk factors for nonunion after foot and ankle arthrodesis.