Preparation and characterization of dual-template molecularly imprinted monolith with metal ion as pivot. (July 2016)

• Record Type: Journal Article
• Authors: Zhang, Jing; Li, Fang; Wang, Xian-Hua; Xu, Dan; Huang, Yan-Ping; Liu, Zhao-Sheng
• Is Part Of: European polymer journal. Volume 80(2016:Jul.)
• Page Start: 134
• Page End: 144
• Publication Date: 2016-07
• Subjects: Molecularly imprinted polymers -- Monolith -- Dual-templates -- Metal ion as pivot -- Affinity; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2016.05.009
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: MDMIM was successfully prepared with Co 2+ as pivot for the first time. MDMIM is more effective for multi-analyte imprinting vs traditionally MIPs. The ratio of two templates was found to exert impact on the imprinting effect of MDMIM. The retention mechanism was steric interaction proved by thermodynamic analysis. Abstract: In this work, a method for improving imprinting efficiency of dual-templates molecularly imprinted polymer was developed based on strategy of metal ion as pivot. Two templates, naproxen (NAP) and ketoprofen (KET), were simultaneously imprinted using 4-vinylpyridine (4-VP) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linker with Co 2+ as pivot. A ternary mixture of dimethyl formamide (DMF)- dimethyl sulfoxide (DMSO)- 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4 ) was used as the porogenic system. The resulting metal ion mediated, dual-templates molecularly imprinted monolith (MDMIM) showed excellent selectivity to the templates and analogues. In contrast to traditionally formulated MIPs made with multi-templates, reduced recognition ability toward targeted analytes on the MDMIM was not found. The structural properties of MDMIM were determined from Fourier transform infrared spectra, mercury intrusion and extrusion experiments and nitrogen adsorption–desorption isotherms. The MDMIM was then tested in the chromatographic mode due to its ability to recognize the templates. The studies of Van't Hoff analysis indicated that the separation of the templates and their analogues on the MDMIM was an enthalpy controlled process. Collectively, metal ion as pivot is demonstrated as an effective method of imprinting dual-templates simultaneously without loss of selectivity.